Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 432050
Title Towards metagenome-scale models for industrial applications-the case of Lactic Acid Bacteria
Author(s) Branco Dos Santos, F.; Vos, W.M. de; Teusink, B.
Source Current Opinion in Biotechnology 24 (2013)2. - ISSN 0958-1669 - p. 200 - 206.
DOI http://dx.doi.org/10.1016/j.copbio.2012.11.003
Department(s) Microbiological Laboratory
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) comparative systems biology - lactobacillus-plantarum - lactococcus-lactis - metabolic reconstruction - intestinal microbiota - escherichia-coli - gut - growth - identification - fermentation
Abstract We review the uses and limitations of modelling approaches that are in use in the field of Lactic Acid Bacteria (LAB). We describe recent developments in model construction and computational methods, starting from application of such models to monocultures. However, since most applications in food biotechnology involve complex nutrient environments and mixed cultures, we extend the scope to discuss developments in modelling such complex systems. With metagenomics and meta-functional genomics data becoming available, the developments in genome-scale community models are discussed. We conclude that exploratory tools are available and useful, but truly predictive mechanistic models will remain a major challenge in the field
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