Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 432214
Title Gut bacteria-host metabolic interplay during conventionalisation of the mouse germfree colon
Author(s) Aidy, S. El; Derrien, M.M.N.; Merrifield, C.A.; Levenez, F.; Dore, J.; Boekschoten, M.V.; Dekker, J.; Holmes, E.; Zoetendal, E.G.; Baarlen, P. van; Claus, S.P.; Kleerebezem, M.
Source ISME Journal 7 (2013). - ISSN 1751-7362 - p. 743 - 755.
DOI http://dx.doi.org/10.1038/ismej.2012.142
Department(s) VLAG
Microbiological Laboratory
Chair Nutrition Metabolism and Genomics
DW ManagementDirectie
Host Microbe Interactomics
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) colorectal-cancer - polysaccharide utilization - selenomonas-ruminantium - human intestine - immune-system - waste-water - microbiota - mice - mucosa - nmr
Abstract The interplay between dietary nutrients, gut microbiota and mammalian host tissues of the gastrointestinal tract is recognised as highly relevant for host health. Combined transcriptome, metabonome and microbial profiling tools were employed to analyse the dynamic responses of germfree mouse colonic mucosa to colonisation by normal mouse microbiota (conventionalisation) at different time-points during 16 days. The colonising microbiota showed a shift from early (days 1 and 2) to later colonisers (days 8 and 16). The dynamic changes in the microbial community were rapidly reflected by the urine metabolic profiles (day 1) and at later stages (day 4 onward) by the colon mucosa transcriptome and metabolic profiles. Correlations of host transcriptomes, metabolite patterns and microbiota composition revealed associations between Bacilli and Proteobacteria, and differential expression of host genes involved in energy and anabolic metabolism. Differential gene expression correlated with scyllo- and myo-inositol, glutamine, glycine and alanine levels in colonic tissues during the time span of conventionalisation. Our combined time-resolved analyses may help to expand the understanding of host-microbe molecular interactions during the microbial establishment
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