Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 432293
Title Asynchronous Supply of Indispensable Amino Acids Reduces Protein Deposition in Milk-Fed Calves
Author(s) Borne, J.J.G.C. van den; Alferink, S.J.J.; Heetkamp, M.J.W.; Jacobs, A.A.A.; Verstegen, M.W.A.; Gerrits, W.J.J.
Source The Journal of Nutrition 142 (2012)12. - ISSN 0022-3166 - p. 2075 - 2082.
Department(s) Animal Nutrition
Adaptation Physiology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) bound lysine - growing-pigs - preruminant calves - alpha-ketoisocaproate - leucine oxidation - balance technique - healthy-adults - delayed lysine - fat deposition - wheat gluten
Abstract A balanced supply of indispensable amino acids (AA) is required for efficient protein synthesis. Different absorption kinetics (e.g., free vs. protein-bound AA) may, however, create asynchrony in postabsorptive availability of individual AA, thereby reducing the efficiency of protein deposition. We studied the effects of AA asynchrony on protein metabolism in growing, milk-fed calves. In 2 experiments, each with a change-over design including 8 calves, a milk replacer deficient in Lys and Thr was used. In Expt. 1, l-Lys and l-Thr were parenterally supplemented, either in synchrony (SYN), asynchrony (ASYN), or partial asynchrony (PART) with dietary AA. In Expt. 2, l-Lys and l-Thr were orally supplemented, either in SYN or ASYN with dietary AA. In Expt. 1, digested protein was used less efficiently for growth for ASYN (31.0%) than for SYN (37.7%), with PART being intermediate (36.0%). Indicator AA oxidation tended (P = 0.06) to be higher for ASYN. In Expt. 2, the efficiency of protein utilization was lower for ASYN (34.9%) than for SYN (46.6%). Calves spared AA from oxidation when the limiting AA were provided in excess after a short period (
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