Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 433407
Title A PHABULOSA/Cytokinin feedback loop controls root growth in Arabidopsis
Author(s) Dello loio, R.; Galinha, C.; Fletcher, A.G.; Grigg, S.P.; Molnar, A.; Willemsen, V.; Scheres, B.
Source Current Biology 22 (2012)18. - ISSN 0960-9822 - p. 1699 - 1704.
DOI http://dx.doi.org/10.1016/j.cub.2012.07.005
Department(s) Plant Developmental Biology
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) stem-cell niche - gene family - cytokinin - meristem - auxin - differentiation - expression - polarity - biosynthesis - nitrate
Abstract The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations.
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