Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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Record number 433694
Title Diets poor in fibre, vegetable protein and polyunsaturated fat are associated with inflammation and endothelial dysfunction in type 1 diabetes mellitus: the EURODIAB study
Author(s) Bussel, B.C.T. van; Soedamah-Muthu, S.S.; Henry, R.M.A.; Schalkwijk, C.G.; Ferreira, I.; Chaturvedi, N.; Toeller, M.; Fuller, J.H.; Stehouwer, C.D.A.
Source In: Abstracts of the 47th EASD Annual Meeting, Lisbon, Portugal, 12-16 September 2011. - - p. S12 - S13.
Event 47th EASD Annual Meeting, Lisbon, Portugal, 2011-09-12/2011-09-16
Department(s) Chair Nutrition and Disease
Publication type Abstract in scientific journal or proceedings
Publication year 2011
Abstract Background and aims: To investigate the association between nutrient consumption and biomarkers of endothelial dysfunction (ED) and low-grade inflammation (LGI) in type 1 diabetes mellitus. Materials and methods: We investigated 491 individuals. Nutrient consumption and lifestyle risk factors were measured in 1989 and 1997. Biomarkers of ED (von Willebrand factor, soluble vascular cell adhesion molecule-1 and soluble endothelial selectin) and LGI (C-reactive protein, interleukin-6 and tumour necrosis factor-a) were measured in 1997 and averaged into z scores. Nutrients were adjusted for total energy intake by the nutrient residual method. Data were analysed with generalised estimating equations. We report average 8-year differences in nutrient consumption per +1 standard deviation (SD) of 1997 ED or LGI z scores. Results are adjusted for sex, age, duration of diabetes, investigation centre, body mass index, energy intake, smoking behaviour and alcohol consumption, and other nutrients. Results: A one SD elevation in endothelial dysfunction z score was associated with a diet over an 8-year period that was lower in fibre [ß(95%CI); -0.09(-0.18;-0.004)], polyunsaturated fat [-0.18(-0.32;-0.05)] and vegetable protein [-0.10(-0.20;-0.001)]. For the low-grade inflammation z score the results showed a diet lower in fibre [-0.09(-0.17;-0.01)] and polyunsaturated fat [-0.14(-0.24;-0.03)], and higher in cholesterol [0.10(0.01;0.18)]. Conclusion: In type 1 diabetes mellitus, consumption of less fibre, polyunsaturated fat and vegetable protein and more cholesterol over an 8-year study period was associated with more ED and LGI. This supports the hypothesis that following the current dietary guidelines in type 1 diabetes mellitus may reduce cardiovascular disease risk by affecting ED and LGI favourably
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