Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 433694
Title Diets poor in fibre, vegetable protein and polyunsaturated fat are associated with inflammation and endothelial dysfunction in type 1 diabetes mellitus: the EURODIAB study
Author(s) Bussel, B.C.T. van; Soedamah-Muthu, S.S.; Henry, R.M.A.; Schalkwijk, C.G.; Ferreira, I.; Chaturvedi, N.; Toeller, M.; Fuller, J.H.; Stehouwer, C.D.A.
Source In: Abstracts of the 47th EASD Annual Meeting, Lisbon, Portugal, 12-16 September 2011. - - p. S12 - S13.
Event 47th EASD Annual Meeting, Lisbon, Portugal, 2011-09-12/2011-09-16
Department(s) Chair Nutrition and Disease
VLAG
Publication type Abstract in scientific journal or proceedings
Publication year 2011
Abstract Background and aims: To investigate the association between nutrient consumption and biomarkers of endothelial dysfunction (ED) and low-grade inflammation (LGI) in type 1 diabetes mellitus. Materials and methods: We investigated 491 individuals. Nutrient consumption and lifestyle risk factors were measured in 1989 and 1997. Biomarkers of ED (von Willebrand factor, soluble vascular cell adhesion molecule-1 and soluble endothelial selectin) and LGI (C-reactive protein, interleukin-6 and tumour necrosis factor-a) were measured in 1997 and averaged into z scores. Nutrients were adjusted for total energy intake by the nutrient residual method. Data were analysed with generalised estimating equations. We report average 8-year differences in nutrient consumption per +1 standard deviation (SD) of 1997 ED or LGI z scores. Results are adjusted for sex, age, duration of diabetes, investigation centre, body mass index, energy intake, smoking behaviour and alcohol consumption, and other nutrients. Results: A one SD elevation in endothelial dysfunction z score was associated with a diet over an 8-year period that was lower in fibre [ß(95%CI); -0.09(-0.18;-0.004)], polyunsaturated fat [-0.18(-0.32;-0.05)] and vegetable protein [-0.10(-0.20;-0.001)]. For the low-grade inflammation z score the results showed a diet lower in fibre [-0.09(-0.17;-0.01)] and polyunsaturated fat [-0.14(-0.24;-0.03)], and higher in cholesterol [0.10(0.01;0.18)]. Conclusion: In type 1 diabetes mellitus, consumption of less fibre, polyunsaturated fat and vegetable protein and more cholesterol over an 8-year study period was associated with more ED and LGI. This supports the hypothesis that following the current dietary guidelines in type 1 diabetes mellitus may reduce cardiovascular disease risk by affecting ED and LGI favourably
Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.