Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 436860
Title Increased dietary protein intake lowers blood pressure in overweight subjects
Author(s) Dopheide, J.; Geleijnse, J.M.; Bakker, S.J.L.; Brink, E.J.; Baak, M.A. van
Source Journal of Hypertension 29 (2011)Suppl.. - ISSN 0263-6352 - p. e267 - e267.
Department(s) Chair Nutrition and Disease
Publication type Non-refereed article in scientific journal
Publication year 2011
Abstract Objective: Several intervention trials have shown that diet composition affects blood pressure (BP). In this study we focused on the effect of dietary protein content on BP. Design and Method: In this randomized double-blind parallel group study, 94 adult untreated overweight subjects with mildly elevated BP (BMI 25-35 kg/m2, BP > 130/85 and <160/100 mm Hg) were included. After a 2-week run-in period on a weight-maintaining standardized diet (15 en% protein (P), 30 en% fat (F) and 55 en% carbohydrate (C)), subjects were randomized to a high P or a high C diet for 4 weeks. On the high C diet 60 g of C of the run-in diet was replaced by 3x20 g of maltodextrin supplements, on the high P diet 60 g of C was replaced by 3x20 g of a protein supplement (mixture of 20% pea, 20% soy, 30% egg and 30% milk protein isolate). Supplements were matched for Na, P, K, Ca and Mg content and taken with each meal. Office and 24-h ambulatory blood pressures (ABP) were assessed at the end of the run-in and after 4 weeks supplement use. BP differences between groups after 4 weeks were analyzed by ANCOVA with BP at the end of the run-in as covariate. Results :At the end of run-in office BP (mean ± SE) was 142.6 ± 1.6/92.2 ± 0.9 mm Hg in the C and 143.3 ± 1.8/92.9 ± 1.0 mm Hg in the P group; daytime ambulatory BPs were 147.5 ± 1.8/91.0 ± 1.1 mm Hg and 147.2 ± 1.8/92.5 ± 1.2 mm Hg respectively. After 4 weeks, office SBP and DBP were lower in the P than in the C group (-4.9 mm Hg (95% CI -1.5, -8.2), p = 0.005 and - 2.7 mm Hg (95% CI -0.1, -5.4), p = 0.045) and daytime ambulatory SBP tended to be (-4.1 mm Hg (95% CI + 0.2, -8.3), p = 0.06). No significant between-group differences in daytime ambulatory DBP (-1.7 mm Hg (95% CI + 1.3, -4.8), p = 0.26) or night-time BP were found. Conclusions: An increase in dietary protein content, in exchange for dietary carbohydrates (glucose), in a weight-maintaining diet lowers blood pressure in overweight subjects with mild blood pressure elevation.
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