Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 436909
Title Genetic variation in paratuberculosis in dairy populations
Author(s) Hulzen, K.J.E. van; Arendonk, J.A.M. van; Heuven, H.C.M.
Source Utrecht University. Promotor(en): Johan van Arendonk; M. Nielen, co-promotor(en): A.P. Koets; Henri Heuven. - Ede : s.n. - ISBN 9789039358733 - 135 p.
Department(s) Animal Breeding and Genetics
WIAS
Publication type Dissertation at other university (Tutor)
Publication year 2012
Abstract Paratuberculosis, also known as Johne’s disease, is caused by oral uptake of Mycobacterium avium subspecies paratuberculosis (MAP) from the environment. MAP causes granulomatous lesions in the distal part of the ileum in domestic and wild ruminants.Ileal lesions limit sufficient nutrient uptake leading to weight loss and additionally, in animals used for dairy production, infection with paratuberculosis leads to decreased milk production and fertility. In the Dutch Holstein-Friesian dairy cattle population, prevalence of paratuberculosis based on a positive ELISA test in milk was 46.7% on the herd level and 2.4% on the animal level in 2008. Prevalence of paratuberculosis in dairy goat herds is unknown but suspected to be higher than in cattle herds based on clinical and routine pathological observations.The aim of this thesis is to contribute to control of paratuberculosis by investigating genetic variation in the pathogen and studying genetic variation in host susceptibility. Genetic variation of the pathogen was investigated within and between herds in the Netherlands. For host susceptibility to paratuberculosis, genetic variation and heritability were estimated for dairy cattle and dairy goats. For dairy cattle, results from the quantitative genetic analysis were used to perform a genome-wide association study to find chromosomal regions associated with susceptibility to disease. Finally, a genetic-epidemiological model was used to study the effect of genetic selection for increased resistance to paratuberculosis on the prevalence of infection in the dairy cattle population.
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