Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 439140
Title ODoSE: A Webserver for Genome-Wide Calculation of Adaptive Divergence in Prokaryotes
Author(s) Vos, M.; Beek, T.A.H.; Driel, M.A. van; Huynen, M.A.; Eyre-Walker, A.; Passel, M.W.J. van
Source PLoS One 8 (2013)5. - ISSN 1932-6203
DOI https://doi.org/10.1371/journal.pone.0062447
Department(s) Systems and Synthetic Biology
WIMEK
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) positive selection - evolution - recombination - drosophila - campylobacter
Abstract Quantifying patterns of adaptive divergence between taxa is a major goal in the comparative and evolutionary study of prokaryote genomes. When applied appropriately, the McDonald-Kreitman (MK) test is a powerful test of selection based on the relative frequency of non-synonymous and synonymous substitutions between species compared to non-synonymous and synonymous polymorphisms within species. The webserver ODoSE (Ortholog Direction of Selection Engine) allows the calculation of a novel extension of the MK test, the Direction of Selection (DoS) statistic, as well as the calculation of a weighted-average Neutrality Index (NI) statistic for the entire core genome, allowing for systematic analysis of the evolutionary forces shaping core genome divergence in prokaryotes. ODoSE is hosted in a Galaxy environment, which makes it easy to use and amenable to customization and is freely available at www.odose.nl
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