Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 439482
Title Better evolution through gene clustering
Author(s) Slot, J.; Campbell, M.; Zhang, H.; Staats, M.; Kan, J.A.L. van
Source In: Book of Abstracts 27th Fungal Genetics Conference, Asilomar, Pacific Grove, California, USA, 12-17 March 2013. - - p. 75 - 75.
Event 27th Fungal Genetics Conference, 2013-03-12/2013-03-17
Department(s) RIKILT - BU Authenticity & Nutrients
Laboratory of Phytopathology
EPS-2
Publication type Abstract in scientific journal or proceedings
Publication year 2013
Abstract The recent availability of a large number of fungal genomes has facilitated systematic investigations of metabolic pathway evolution across the kingdom. Through combining phylogenetic and genomic techniques, we have recently examined the evolution of metabolic pathways across a well-sampled fungal phylogeny, and gained new insight into the role of metabolic gene clusters in fungal evolution. The occasional occurrence of horizontal gene transfer of entire pathways between distantly related fungi via gene clusters suggests that fungal species have access to larger pan-genomes than previously thought. Furthermore, analysis of gene cluster decay suggests these transfers are underestimated by analyses of single strains, and that evolution within clustered pathways is constrained by natural selection. Increased evolvability in fungi is also implied by the discovery of chromosomal loci that maintain large alternative secondary metabolite gene clusters within recombining lineages. Together, these phylogenomic analyses in fungi illustrate a multi-faceted role of gene clustering in fungal evolution.
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