| Record number | 440441 |
|---|---|
| Title | Genetic analysis of metabolome-phenotype interactions: from model to crop species |
| Author(s) | Carreno Quintero, N.; Bouwmeester, H.J.; Keurentjes, J.J.B. |
| Source | Trends in Genetics 29 (2013)1. - ISSN 0168-9525 - p. 41 - 50. |
| DOI | http://dx.doi.org/10.1016/j.tig.2012.09.006 |
| Department(s) |
Laboratory of Plant Physiology Laboratory of Genetics EPS-3 |
| Publication type | Refereed Article in a scientific journal |
| Publication year | 2013 |
| Keyword(s) | quantitative trait loci - genome-wide association - chromatography-mass spectrometry - functional genomics - arabidopsis-thaliana - mapping population - systems biology - glucosinolate accumulation - secondary metabolism - transcription factor |
| Abstract | The past decade has seen increased interest from the scientific community, and particularly plant biologists, in integrating metabolic approaches into research aimed at unraveling phenotypic diversity and its underlying genetic variation. Advances in plant metabolomics have enabled large-scale analyses that have identified qualitative and quantitative variation in the metabolic content of various species, and this variation has been linked to genetic factors through genetic-mapping approaches, providing a glimpse of the genetic architecture of the plant metabolome. Parallel analyses of morphological phenotypes and physiological performance characteristics have further enhanced our understanding of the complex molecular mechanisms regulating these quantitative traits. This review aims to illustrate the advantages of including assessments of phenotypic and metabolic diversity in investigations of the genetic basis of complex traits, and the value of this approach in studying agriculturally important crops. We highlight the ground-breaking work on model species and discuss recent achievements in important crop species. |
| Comments |
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