Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 440460
Title Behaviour of silver nanoparticles and silver ions in an in vitro human gastrointestinal digestion model
Author(s) Walczak, A.P.; Fokkink, R.G.; Peters, R.J.B.; Tromp, P.; Herrera Rivera, Z.E.; Rietjens, I.M.C.M.; Hendriksen, P.J.M.; Bouwmeester, H.
Source Nanotoxicology 7 (2013)7. - ISSN 1743-5390 - p. 1198 - 1210.
DOI https://doi.org/10.3109/17435390.2012.726382
Department(s) Rikilt B&T Toxicologie en Effectanalyse
Sub-department of Toxicology
Physical Chemistry and Colloid Science
RIKILT - Business unit Contaminants & Toxins
RIKILT - BU Toxicology Bioassays & Novel Foods
RIKILT - Business Unit Safety & Health
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) aggregation kinetics - aqueous-solution - toxicity - dissolution - exposure - fluid - food - nanotechnologies - fabrication - nanosilver
Abstract Oral ingestion is an important exposure route for silver nanoparticles (AgNPs), but their fate during gastrointestinal digestion is unknown. This was studied for 60 nm AgNPs and silver ions (AgNO3) using in vitro human digestion model. Samples after saliva, gastric and intestinal digestion were analysed with SP-ICPMS, DLS and SEM-EDX. In presence of proteins, after gastric digestion the number of particles dropped significantly, to rise back to original values after the intestinal digestion. SEM-EDX revealed that reduction in number of particles was caused by their clustering. These clusters were composed of AgNPs and chlorine. During intestinal digestion, these clusters disintegrated back into single 60 nm AgNPs. The authors conclude that these AgNPs under physiological conditions can reach the intestinal wall in their initial size and composition. Importantly, intestinal digestion of AgNO3 in presence of proteins resulted in particle formation. These nanoparticles (of 20–30 nm) were composed of silver, sulphur and chlorine
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