Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 440808
Title Innovative approaches to reduce animal testing : replace whenever possible, reduce through refinement and mechanistic understanding
Author(s) Ravenzwaay, B. van
Source Wageningen : Wageningen University - ISBN 9789461736161 - 24
Department(s) Sub-department of Toxicology
Publication type Inaugural/farewell address
Publication year 2013
Keyword(s) alternatieven voor dierproeven - dierproeven - in vitro - toxische stoffen - toxicologie - kinetica - modellen - dierenwelzijn - animal testing alternatives - animal experiments - toxic substances - toxicology - kinetics - models - animal welfare
Categories Animal Experimentation / Toxicology (General) / Animal Health and Welfare
Abstract 'Many of the in vitro toxicological studies have not been sufficiently validated to determine their applicability domain, even less have gained regulatory acceptance. Major advantage of in vitro testing today is the early identification of significant hazards in compound development and reduced and targeted animal testing. Replacing complex animal tests may be achieved by a battery of in vitro test addressing the adverse outcome pathway in question. Kinetics models are needed to translate in vitro results into in vivo values.'
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