Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 440981
Title On the role of baculovirus photolyases in DNA repair upon UV damage of occlusion bodies
Author(s) Biernat, M.A.; Caballero, P.; Vlak, J.M.; Oers, M.M. van
Source IOBC/WPRS Bulletin 90 (2013). - p. 137 - 142.
Department(s) Laboratory of Virology
Publication type Refereed Article in a scientific journal
Publication year 2013
Abstract The use of baculoviruses in insect biocontrol is hampered by their sensitivity to ultraviolet (UV) light. This irradiation induces cyclobutane pyrimidine dimers (CPDs) in DNA. CPD-photolyases repair CPDs using visible light. Plusiine baculoviruses encode photolyases, which could potentially repair UV-damage prior to infection of larvae. Whether the photolyases encoded by Chrysodeixis chalcites nucleoplyhedrovirus are involved in UV damage repair was tested by infecting larvae with UV-irradiated viral occlusion bodies (OBs) that were subsequently treated with visible light or kept in the dark. The observed mortality was the same for both treatments. We postulate that photolyases are not active as DNA repair enzymes in OBs, but may play a role in other aspects of baculovirus pathogenesis.
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