Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 441254
Title Dietary Acid Load and Metabolic Acidosis in Renal Transplant Recipients
Author(s) Berg, Else van den; Engberink, M.F.; Brink, E.J.; Baak, M.A. van; Joosten, M.M.; Gans, R.O.B.; Navis, G.; Bakker, S.J.L.
Source Clinical Journal of the American Society of Nephrology 7 (2012)11. - ISSN 1555-9041 - p. 1811 - 1818.
DOI https://doi.org/10.2215/CJN.04590512
Department(s) Human Nutrition (HNE)
Chair Nutrition and Disease
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) cadaver kidney homotransplantation - food-frequency questionnaire - nutrition examination survey - glomerular-filtration-rate - serum anion gap - tubular-acidosis - blood-pressure - insulin-resistance - national-health - protein-intake
Abstract Background and objectives Acidosis is prevalent among renal transplant recipients (RTRs) and adversely affects cardiometabolic processes. Factors contributing to acidosis are graft dysfunction and immunosuppressive drugs. Little is known about the potential influence of diet on acidosis in RTRs. This study examined the association of metabolic acid load with acidosis and with cardiovascular risk factors in RTRs and aimed to identify dietary factors associated with acidosis. Design, participants, setting, & measurements 707 RTRs were included. Metabolic acid load was assessed by measuring 24-hour urinary net acid excretion (NAE; i.e., titratable acid + ammonium - bicarbonate). Acidosis was defined as serum [HCO3-] <24 mmol/L. BP and insulin resistance, reflected by hemoglobin A1c, were among cardiovascular risk factors. Diet was assessed with food-frequency questionnaires. Linear regression analysis was applied to investigate association between NAE and acidosis and between dietary factors and acidosis. Results Mean age +/- SD was 53 +/- 13 years; 57% of patients were male. Acidosis was present in 31% of RTRs. NAE was associated with acidosis (serum HCO3-: beta=-0.61; serum pH: beta=-0.010; both P
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