Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 441341
Title Novel Multilayer IR-786-loaded Nanocarriers for Intracellular Delivering: Characterization, Imaging, and Internalization in Human Cancer Cell Lines
Author(s) Bazylinska, U.; Saczko, J.; Zielinska, K.; Wilk, K.A.
Source Chemistry Letters / Chemical Society of Japan 41 (2012)10. - ISSN 0366-7022 - p. 1354 - 1356.
Department(s) Physical Chemistry and Colloid Science
Publication type Refereed Article in a scientific journal
Publication year 2012
Keyword(s) nanocapsules
Abstract We aimed to fabricate new oil-core polyelectrolyte-shell nanocapsules loaded with IR-786 cyanine, a third generation photosensitizer, and to evaluate their biocompatibility upon different human cancer cell lines, i.e., breast (MCF-7/WT), skin melanoma (MEWO), and lung (A549). The nanocarriers were fabricated via direct layer-by-layer adsorption of polyanionic poly(L-glutamic acid) sodium salt (PGA) and polycationic poly(L-lysine) (PLL) on a positively charged nanoemulsion template stabilized by N,N-bis[3,3'-(trimethylammonio)propyl]-dodecaneamide dimethylsulfate, C-12(TAPAMS)(2). All studied nanocapsules demonstrated good capacity for IR-786 encapsulation, cellular internalization, and low cytotoxicity.
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