We aimed to fabricate new oil-core polyelectrolyte-shell nanocapsules loaded with IR-786 cyanine, a third generation photosensitizer, and to evaluate their biocompatibility upon different human cancer cell lines, i.e., breast (MCF-7/WT), skin melanoma (MEWO), and lung (A549). The nanocarriers were fabricated via direct layer-by-layer adsorption of polyanionic poly(L-glutamic acid) sodium salt (PGA) and polycationic poly(L-lysine) (PLL) on a positively charged nanoemulsion template stabilized by N,N-bis[3,3'-(trimethylammonio)propyl]-dodecaneamide dimethylsulfate, C-12(TAPAMS)(2). All studied nanocapsules demonstrated good capacity for IR-786 encapsulation, cellular internalization, and low cytotoxicity.
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