Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 441723
Title Serum 25-hydroxyvitamin D is associated with cognitive executive function in Dutch prefrail and frail elderly: a cross-sectional study exploring the associations of 25-hydroxyvitamin D with glucose metabolism, cognitive performance and depression
Author(s) Brouwer, E.M.; Nieuwerth-van de Rest, O.; Tieland, C.A.B.; Zwaluw, N.L. van der; Steegenga, W.T.; Adam, J.J.; Loon, L.J.C. van; Feskens, E.J.M.; Groot, C.P.G.M. de
Source Journal of the American Medical Directors Association 14 (2013)1. - ISSN 1525-8610 - p. 852.e9 - 852.e17.
DOI https://doi.org/10.1016/j.jamda.2013.06.010
Department(s) Chair Nutrition and Disease
Chair Nutrition and Health over the Lifecourse
Human Nutrition (HNE)
Chair Nutrition Metabolism and Genomics
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) randomized controlled-trial - vitamin-d supplementation - placebo-controlled trial - parathyroid-hormone - insulin-resistance - double-blind - older women - risk-factors - us adults - population
Abstract Objectives: The primary objective was to explore the possible association of serum 25-hydroxyvitamin D (25[OH] D) and vitamin D intake with markers of glucose metabolism, depression, and cognitive performance. In addition, we examined to what extent the associations between vitamin D and cognitive performance were modified or mediated by fasting plasma glucose (FPG) levels. Design, Setting, and Participants: Cross-sectional study using data of 127 frail or prefrail Dutch elderly, aged 65 years or older. Frailty was defined according to the criteria of Fried and colleagues. A participant was classified prefrail when 1 to 2 criteria were met; frailty was classified as the presence of 3 or more criteria. Measurements: Associations of 25(OH) D and vitamin D intake with markers of glucose metabolism and domain-specific cognitive performance were examined by multivariable regression analyses. The possible association of vitamin D with depression and global cognitive performance was explored by Poisson regression. Results: No associations were observed for 25(OH) D with FPG, fasting plasma insulin (FPI), Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR), or depression. In contrast, serum 25(OH) D was positively associated with executive functioning (beta 0.007, P=.01) and tended to be associated with information-processing speed (beta 0.006, P=.06). FPG did not modify or mediate these associations. Vitamin D intake was not associated with cognitive performance, glucose metabolism, or depression. Conclusion: This cross-sectional study suggests an association of serum 25(OH) D with domain-specific cognitive performance, in particular executive functioning and possibly information-processing speed, but not with FPG, FPI, HOMA-IR, or depression. Whether these associations are causal is yet to be demonstrated. Copyright (C) 2013 - American Medical Directors Association, Inc.
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