Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 442319
Title Richness of human gut microbiome correlates with metabolic markers
Author(s) Chatelier, E. Le; Nielsen, T.; Qin, J.; Prifti, E.; Hildebrand, F.; Falony, G.; Almeida, M.; Arumugam, M.; Batto, J.M.; Kennedy, S.; Leonard, P.; Li, J.; Burgdorf, K.; Grarup, N.; Jorgensen, T.; Branslund, I.; Nielsen, H.B.; Juncker, A.S.; Bertalan, M.; Levenez, F.; Pons, N.; Rasmussen, S.; Sunagawa, S.; Tap, J.; Tims, S.; Zoetendal, E.G.; Brunak, S.; Clement, K.; Dore, J.; Kleerebezem, M.; Kristiansen, K.; Renault, P.; Sicheritz-Ponten, T.; Vos, W.M. de; Zucker, J.D.; Raes, J.; Hansen, T.; Bork, P.; Wang, J.; Ehrlich, S.D.; Pederson, O.; Guedon, E.; Delorme, C.; Layec, S.; Khaci, G.; Guchte, M. van de; Vandemeulebrouck, G.; Jamet, A.; Dervyn, R.; Sanchez, N.; Maguin, E.; Haimet, F.; Winogradski, Y.; Cultrone, A.; Leclerc, M.; Juste, C.; Blottière, H.; Pelletier, E.; LePaslier, D.; Artiguenave, F.; Bruls, T.; Weissenbach, J.; Turner, K.; Parkhill, J.; Antolin, M.; Manichanh, C.; Casellas, F.; Boruel, N.; Varela, E.; Torrejon, A.; Guarner, F.; Denariaz, G.; Derrien, M.; Hylckama Vlieg, J.E.T. van; Veiga, P.; Oozeer, R.; Knol, J.; Rescigno, M.; Brechot, C.; M'Rini, C.; Mérieux, A.; Yamada, T.
Source Nature 500 (2013)7464. - ISSN 0028-0836 - p. 541 - 546.
DOI http://dx.doi.org/10.1038/nature12506
Department(s) Microbiological Laboratory
Host Microbe Interactomics
VLAG
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) body-mass index - diet-induced obesity - insulin-resistance - wide association - reared apart - weight-loss - inflammation - adiposity - disease - twins
Abstract We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Comments
There are no comments yet. You can post the first one!
Post a comment
 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.