Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 442883
Title WalK, the path towards new antibacterials with low potential for resistance development
Author(s) Velikova, N.R.; Bem, A.E.; Baarlen, P. van; Wells, J.; Marina, A.
Source ACS Medicical Chemistry Letters 4 (2013)10. - ISSN 1948-5875 - p. 891 - 894.
DOI http://dx.doi.org/10.1021/ml400320s
Department(s) Host Microbe Interactomics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) streptococcus-pneumoniae - signal-transduction - histidine kinase - discovery - inhibitors - system - genes
Abstract Resistance to antibiotics used in the treatment of bacterial infectious diseases is a global health problem. More than a decade ago, two-component systems such as WalKR were proposed as ideal targets for the development of new antibiotics. Biochemical screens for WalKR inhibitors using compound libraries have identified many hits, some of which were shown to have non-specific effects. The recently published structures of the S. mutans and B. subtilis WalK provide the opportunity to study inhibitors of WalK autophosphorylation at the atomic level and means to design compounds with improved specificity and affinity using a structure-based approach.
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