Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 442947
Title A mathematical model representing cellular immune development and response to Salmonella of chicken intestinal tissue
Author(s) Schokker, D.; Bannink, A.; Smits, M.A.; Rebel, J.M.J.
Source Journal of Theoretical Biology 330 (2013). - ISSN 0022-5193 - p. 75 - 87.
DOI https://doi.org/10.1016/j.jtbi.2013.04.005
Department(s) LR - Animal Breeding & Genomics
LR - Animal Nutrition
Livestock Research
CVI Infection Biology
Host Microbe Interactomics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) enterica serovar typhimurium - gene-expression responses - t-cells - intraepithelial lymphocytes - mycobacterium-tuberculosis - in-vivo - virulent salmonellae - jejunal development - oral challenge - b lymphocytes
Abstract The aim of this study was to create a dynamic mathematical model of the development of the cellular branch of the intestinal immune system of poultry during the first 42 days of life and of its response towards an oral infection with Salmonella enterica serovar Enteritidis. The system elements were grouped in five important classes consisting of intra- and extracellular S. Enteritidis bacteria, macrophages, CD4+, and CD8+ cells. Twelve model variables were described by ordinary differential equations, including 50 parameters. Parameter values were estimated from literature or from own immunohistochemistry data. The model described the immune development in non-infected birds with an average R² of 0.87. The model showed less accuracy in reproducing the immune response to S. Enteritidis infection, with an average R² of 0.51, although model response did follow observed trends in time. Evaluation of the model against independent data derived from several infection trials showed strong/significant deviations from observed values. Nevertheless, it was shown that the model could be used to simulate the effect of varying input parameters on system elements response, such as the number of immune cells at hatch. Model simulations allowed one to study the sensitivity of the model outcome for varying model inputs. The initial number of immune cells at hatch was shown to have a profound impact on the predicted development in the number of systemic S. Enteritidis bacteria after infection. The theoretical contribution of this work is the identification of responses in system elements of the developing intestinal immune system of poultry obtaining a mathematical representation which allows one to explore the relationships between these elements under contrasting environmental conditions during different stages of intestinal development.
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