Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 447711
Title the potential for enhancement of immunity in cats by dietary supplementation
Author(s) Rutherfurd-Markwick, K.J.; Hendriks, W.H.; Morel, P.C.H.; Thomas, D.G.
Source Veterinary Immunology and Immunopathology 152 (2013)3-4. - ISSN 0165-2427 - p. 333 - 340.
DOI https://doi.org/10.1016/j.vetimm.2013.01.007
Department(s) Animal Nutrition
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) macrophage phagocytic-activity - randomized controlled-trial - arginine supplementation - lymphocyte subsets - cell-function - nucleotides - mice - nutrition - system - acid
Abstract This study was conducted to examine the potential benefits of dietary supplementation on the feline immune system. Forty three cats (8 or 9 per group) were fed a low protein control diet (22.7% DM basis), the same diet supplemented with yeast-derived nucleotides, salmon oil or l-arginine or a commercial moist high protein diet (53.0% DM basis) for a period of five weeks. The low protein diets were formulated using a commercial moist diet base with added fat and starch and fed ad libitum, along with water. Specific immune assays showed that supplementation with arginine caused a significant enhancement of lymphocyte proliferative responses to the T-cell mitogen PHA after 35 days (P = 0.018), while supplementation with either nucleotides or salmon oil resulted in significant enhancement after both 14 (P = 0.0048, P <0.0001 respectively) and 35 days (both P <0.0001). Dietary supplementation with arginine, nucleotides or salmon oil each led to significant increases in blood leucocyte phagocytic activity after both 14 (P = 0.0003, P = 0.0077, P <0.0001 respectively) and 35 days (P <0.0001). This indicates that a number of dietary ingredients have the ability to modulate the immune system of healthy cats possibly resulting in a greater ability to fight infection and disease
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