Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 448263
Title Screening methods and recent developments in the detection of anticoccidials
Author(s) Huet, A.C.; Bienenmann-Ploum, M.E.; Vincent, U.; Delahaut, P.
Source Analytical and Bioanalytical Chemistry 405 (2013)24. - ISSN 1618-2642 - p. 7733 - 7751.
DOI http://dx.doi.org/10.1007/s00216-013-7035-6
Department(s) RIKILT - BU Toxicology Bioassays & Novel Foods
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) tandem mass-spectrometry - performance liquid-chromatography - linked-immunosorbent-assay - time-resolved fluoroimmunoassay - fluorescence polarization immunoassay - uv spectrophotometric detection - antibody-based immunoassay - feed additive nicarbazin - chain v
Abstract This article presents a review of the current trends in the analysis of coccidiostats in various matrices, focusing principally on screening and rapid methods. Coccidiosis is an infectious disease having a high negative impact on the animal industry. Drugs are therefore necessary to prevent and/or to combat this disease. However, it is also of crucial importance that these veterinary drugs do not enter the human food chain. European legislation has therefore established the boundaries for the use of coccidiosats and has also addressed the unavoidable problem of cross-contamination of the feed, mainly caused by the use of the same production lines. Consequently there is a need for analytical methods and/or analytical strategies for the monitoring and control of the residues of anticoccidials, both in feed and in the resulting matrices for human consumption. In the frame of the European collaborative project CONffIDENCE, such attempts to establish the required analytical tools were made, which required beforehand a review of the state of the art in this domain. Aiming at this objective, in this review we consider themost interesting publications since 2000. In essence, both a rapid approach with mainly immunoassays and chromatographic methods were developed. To date, the obstacle to routine use of the first approach has been its inability to detect more than two compounds simultaneously, but recent developments in flow cytometry have made it possible to detect six coccidiostats at once. On the other hand, an increasingly popular approach for detecting multiple coccidiostats simultaneously is liquid chromatography coupledwith tandemmass spectrometry. There remains a need to adapt these analytical methods to legislative requirements.
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