Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 448361
Title Mechanisms underlying the dualistic mode of action of major soy isoflavones in relation to cell proliferation and cancer risks
Author(s) Rietjens, I.M.C.M.; Sotoca, A.M.; Vervoort, J.; Louisse, J.
Source Molecular Nutrition & Food Research 57 (2013)1. - ISSN 1613-4125 - p. 100 - 113.
DOI http://dx.doi.org/10.1002/mnfr.201200439
Department(s) Sub-department of Toxicology
Biochemistry
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) estrogen-receptor-beta - randomized controlled-trial - health initiative memory - mediated gene-regulation - tumor-suppressor genes - breast-cancer - prostate-cancer - postmenopausal women - in-vitro - messenger-rna
Abstract Isoflavones are phytoestrogens that have been linked to both beneficial as well as adverse effects in relation to cell proliferation and cancer risks. The present article presents an overview of these seemingly contradicting health effects and of mechanisms that could be involved in this dualistic mode of action. One mechanism relates to the different ultimate cellular effects of activation of estrogen receptor (ER) a, promoting cell proliferation, and of ERß, promoting apoptosis, with the major soy isoflavones genistein and daidzein activating especially ERß. A second mode of action includes the role of epigenetics, including effects of isoflavones on DNA methylation, histone modification and miRNA expression patterns. The overview presented reveals that we are only at the start of unraveling the complex underlying mode of action for effects of isoflavones, both beneficial or adverse, on cell proliferation and cancer risks. It is evident that whatever model system will be applied, its relevance to human tissues with respect to ERa and ERß levels, co-repressor and co-activator characteristics as well as its relevance to human exposure regimens, needs to be considered and defined
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