Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 448438
Title The association between drugs frequently used by the elderly and vitamin D blood levels: a review of observational and experimental studies
Author(s) Orten-Luiten, A.C.B. van; Janse, A.; Dhonukshe-Rutten, R.A.M.; Witkamp, R.F.
Source Drugs & Aging 31 (2014)2. - ISSN 1170-229X - p. 111 - 123.
Department(s) Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Pharmacology (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) bone-mineral density - intestinal calcium-absorption - hypertensive hemodialyzed patients - nonrheumatic atrial-fibrillation - previous hemispheric infarction - oral anticoagulant-therapy - type-2 diabetes-mellitus - nursing-home residents - 25 hydroxyvitamin-d
Abstract The risk of adverse drug reactions (ADRs) rises with increasing age. In the field of ADRs, drug–nutrient interactions (DNIs) are a relatively unexplored area. More knowledge will contribute to the simple prevention of this type of ADR. As the prevalence of vitamin D deficiency in the elderly is high, the primary objective of this review is to evaluate the literature on the relationship between drug use and vitamin D status, focusing on medicines commonly used by the elderly. PubMed was searched for human epidemiological and clinical studies published until early 2013, investigating the relationship between vitamin D blood levels and use of drugs from one of the following groups: proton pump inhibitors (PPIs), biguanides, vitamin K antagonists, platelet aggregation inhibitors, thiazide diuretics, loop diuretics, beta-blocking agents, calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors, angiotensin-II antagonists, statins, benzodiazepines, and antidepressants. A total of 63 publications were identified. Thiazide diuretics, statins, and calcium channel blocking agents were the most frequently studied drug groups. Associations between thiazides and vitamin D were mixed (n = 22), statins had no or positive associations (n = 16) and calcium blockers were not associated or were negatively associated with vitamin D (n = 10). In conclusion, several knowledge gaps exist on the relationship between drug use and vitamin D blood levels. Available data are scarce (particularly for the aged), study characteristics are highly variable, and found associations may be confounded by, amongst other things, the underlying disease. Nonetheless, this review provides a basis for future research on ADRs that contribute to nutrient deficiencies.
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