Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 448616
Title Sports doping: Emerging designer and therapeutic B2-agonists
Author(s) Fragkaki, A.G.; Georgakopoulos, C.; Sterk, S.S.; Nielen, M.W.F.
Source Clinica Chimica Acta 425 (2013). - ISSN 0009-8981 - p. 242 - 258.
Department(s) RIKILT - Business unit Dierbehandelingsmiddelen
RIKILT Directie
Laboratory for Organic Chemistry
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) acting beta(2)-adrenoreceptor agonists - chromatography-mass spectrometry - molecularly imprinted polymers - obstructive pulmonary-disease - beta-adrenergic agonists - performance liquid-chromatography - 2-dimensional gas-chromatography - developed bronchodilati
Abstract Beta2-adrenergic agonists, or ß2-agonists, are considered essential bronchodilator drugs in the treatment of bronchial asthma, both as symptom-relievers and, in combination with inhaled corticosteroids, as disease-controllers. The use of ß2-agonists is prohibited in sports by the World Anti-Doping Agency (WADA) due to claimed anabolic effects, and also, is prohibited as growth promoters in cattle fattening in the European Union. This paper reviews the last seven-year (2006-2012) literature concerning the development of novel ß2-agonists molecules either by modifying the molecule of known ß2-agonists or by introducing moieties producing indole-, adamantyl- or phenyl urea derivatives. New emerging ß2-agonists molecules for future therapeutic use are also presented, intending to emphasize their potential use for doping purposes or as growth promoters in the near future.
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