Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 448971
Title Update on cardiometabolic health effects of w-3 fatty acids
Author(s) Kromhout, D.; Goede, J. de
Source Current Opinion in Lipidology 25 (2014)1. - ISSN 0957-9672 - p. 85 - 90.
DOI https://doi.org/10.1097/MOL.0000000000000041
Department(s) Chair Nutrition and Disease
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) randomized controlled-trials - polyunsaturated fatty-acids - implantable cardioverter-defibrillators - long-chain omega-3-fatty-acids - fish consumption - cardiovascular-disease - myocardial-infarction - cardiac-arrhythmias - atrial-fibrillation - arterial stiffne
Abstract PURPOSE OF REVIEW: The fish fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) may promote cardiometabolic health. This review summarizes the results of recent meta-analyses of prospective studies on cardiovascular diseases, diabetes type 2 and markers of atherosclerosis and thrombosis. RECENT FINDINGS: The results of recently published meta-analyses of prospective cohort studies showed that eating fish once a week was associated with a 16% lower risk of fatal coronary heart disease (CHD) and a 14% lower risk of stroke incidence, but was not related to heart failure. Fish consumption may be associated with a higher risk of diabetes in Western countries and a lower risk in Asian countries. Recent meta-analyses of randomized controlled trials showed that EPA-DHA supplementation reduced the risk of fatal CHD and sudden death by 10% of which the latter was not significant. Extra EPA-DHA did not reduce the risk of heart failure, stroke and cardiac arrhythmias. ¿-3 fatty acid (FA) supplementation did reduce markers of ventricular fibrillation, inflammation and endothelial dysfunction and platelet aggregation. SUMMARY: There is strong evidence for a protective effect of ¿-3 FA on fatal CHD and for some markers of atherosclerosis and thrombosis. Consistent results were not obtained for other vascular diseases and diabetes. ¿-3 FA reduced markers of ventricular fibrillation but did not reduce the risk of atrial fibrillation.
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