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Record number 449903
Title Coral aquaculture to support drug discovery
Author(s) Leal, M.C.; Calado, R.; Sheridan, C.; Alimonti, A.; Osinga, R.
Source Trends in Biotechnology 31 (2013)10. - ISSN 0167-7799 - p. 555 - 561.
DOI https://doi.org/10.1016/j.tibtech.2013.06.004
Department(s) Aquaculture and Fisheries
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) reef restoration - natural-products - sinularia-flexibilis - cultivation - growth - mucus - bacteria - diseases - ecology - sponges
Abstract Marine natural products (NP) are unanimously acknowledged as the blue gold in the urgent quest for new pharmaceuticals. Although corals are among the marine organisms with the greatest diversity of secondary metabolites, growing evidence suggest that their symbiotic bacteria produce most of these bioactive metabolites. The ex hospite culture of coral symbiotic microbiota is extremely challenging and only limited examples of successful culture exist today. By contrast, in toto aquaculture of corals is a commonly applied technology to produce corals for aquaria. Here, we suggest that coral aquaculture could as well be a viable and economically feasible option to produce the biomass required to execute the first steps of the NP-based drug discovery pipeline.
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