Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 455896
Title Fame and future of faecal transplantations - developing next-generation therapies with synthetic microbiomes
Author(s) Vos, W.M. de
Source Microbial Biotechnology 6 (2013)4. - ISSN 1751-7907 - p. 316 - 325.
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2013
Keyword(s) recurrent clostridium-difficile - gastrointestinal-tract microbiota - 16s ribosomal-rna - human gut - intestinal microbiota - ulcerative-colitis - narrow-spectrum - bowel-syndrome - bacteriotherapy - diversity
Abstract While practised for over thousand years, there is presently a renaissance in the interest of using of faecal transplantations to modify the intestinal microbiota of patients. This clinical practice consists of delivering large amounts of bowel microbes in various forms into the intestinal tract of the recipient that usually has been cleared previously. The major reason for the popularity of faecal transplantations is their effectiveness in treating a variety of diseases. Hence, there is a need to develop this procedure to the next level. While there are various developments to select, standardize and store the donor microbiota, it is more challenging to understand the intestinal microbial communities and develop ways to deliver these via robust biotechnological processes. The various approaches that have been followed to do so are discussed in this contribution that is also addressing the concept of the minimal microbiome as well as the production of the synthetic communities that can be instrumental in new therapeutic avenues to modify the intestinal microbiota.
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