Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 477182
Title The endocannabinoid system: an emerging key player in inflammation
Author(s) Witkamp, R.F.; Meijerink, J.
Source Current Opinion in Clinical Nutrition and Metabolic Care 17 (2014)2. - ISSN 1363-1950 - p. 130 - 138.
DOI http://dx.doi.org/10.1097/MCO.0000000000000027
Department(s) Chair Nutrition and Pharmacology (HNE)
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) acid amide hydrolase-1 - cancer cell-lines - cannabinoid receptor - n-acylethanolamines - endogenous cannabinoids - docosahexaenoic acid - signaling pathways - lipid mediator - ppar-gamma - fish-oil
Abstract Purpose of review: The purpose of this review is to illustrate the expanding view of the endocannabinoid system (ECS) in relation to its roles in inflammation. Recent findings: According to the formal classification, the ECS consists of two cannabinoid receptors, their endogenous fatty acid-derived ligands, and a number of enzymes involved in their synthesis and breakdown. However, many endogenous congeners of classical endocannabinoids have now been discovered, together with a set of receptors structurally or functionally related to the cannabinoid receptors. Endocannabinoids per se behave ‘promiscuously’ with regard to their receptor interactions. It is increasingly recognized how tightly this expanded ECS is intertwined with key processes involved in inflammation. A continuous dynamic exchange of substrates and metabolites exists between ECS and eicosanoid pathways. Endocannabinoids can also be oxygenated by cyclooxygenase and other enzymes to biologically active ‘hybrid’ structures. Diet is among the main factors determining synthesis and release of endocannabinoids and related mediators. Summary: The complexity of what may be called the ‘endocannabinoidome’ requires approaches that take into account its dynamics and interconnections with other regulatory systems. This endocannabinoidome continues to offer possibilities for prevention and intervention, but multiple target approaches will probably provide the only keys to success.
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