Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 477413
Title Screening of protein biomarkers for sports doping and veterinary control
Author(s) Ludwig, S.K.J.; Ginkel, L.A. van; Nielen, M.W.F.
Source TrAC : Trends in Analytical Chemistry 57 (2014). - ISSN 0165-9936 - p. 47 - 63.
Department(s) RIKILT - Business unit Dierbehandelingsmiddelen
RIKILT Directie
Laboratory for Organic Chemistry
Publication type Refereed Article in a scientific journal
Publication year 2014
Keyword(s) recombinant bovine somatotropin - growth-hormone treatment - igf-i - mass-spectrometry - skeletal-muscle - promoter abuse - insulin misuse - veal calves - serum - gh
Abstract There are similarities between sports doping and veterinary control. Prohibited substances (e.g., anabolic agents and peptide hormones) are similar, and immunoassays and chromatography-mass spectrometry are applied as analytical methods in both worlds. In recent years, detection strategies based on protein biomarkers were successfully developed and adopted in sports control. When measuring biomarkers, the window of detection can be extended due to a prolonged biological response, so a whole range of substances may be tackled in an indirect manner. In view of the similarities in intended biological effects, such as increased muscle mass, we envisage that biomarker-based detection may be adopted veterinary control in future. In this review, we discuss detection strategies based on protein biomarkers for biomarker discovery and method development. With the lessons learnt from successfully implementing biomarker strategies in doping regulations, we advocate adoption in the veterinary world and revision of the current restrictive regulations concerning analytical methods.
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