Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 478605
Title Fine-mapping of a candidate region associated with milk-fat composition on Bos taurus autosome 17
Author(s) Duchemin, S.I.; Visker, M.H.P.W.; Arendonk, J.A.M. van; Bovenhuis, H.
Event 10th World Congress on Genetics Applied to Livestock Production WCGALP 2014, Vancouver, Canada, 2014-08-17/2014-08-22
Department(s) Animal Breeding and Genetics
WIAS
Publication type Poster (professional)
Publication year 2014
Abstract A genomic region associated with milk-fat composition has been detected on BTA17. However, no candidate gene or causal variant has been identified so far. Our goal was to fine-map this region by using imputed 777k SNP genotypes. Phenotypes and genotypes were available on 1,581 animals. Phenotypes consisted of gas chromatography measurements of C8:0, and genotypes consisted of the imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. Based on these SNP, haplotypes were constructed. Haplotypes suggested the presence of one QTL within the fine-mapped region. This QTL explained 9% of the genetic variation in C8:0. Although many genes are present in this QTL region, most of these genes have not been characterized yet. Therefore, no clear candidate gene associated with milk-fat composition could be identified.
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