Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 480104
Title PPARs: important regulators in metabolism and inflammation
Author(s) Sanderson, L.; Kersten, A.H.
Source In: Nuclear Receptors : current concepts and future challenges / Bunce, C.M., Campbell, M.J., Dordrecht : Springer-Verlag (Proteins and cell regulation 8) - ISBN 9789048133024 - p. 259 - 285.
DOI http://dx.doi.org/10.1007/978-90-481-3303-1_10
Department(s) Chair Nutrition Metabolism and Genomics
VLAG
Publication type Peer reviewed book chapter
Publication year 2010
Abstract The ligand-activated family of peroxisome proliferator activated receptors (PPARs) consists of three members named PPARα, PPARδ and PPARγ. Each PPAR subtype is characterized by a specific tissue expression pattern, partially accounting for distinct biological functions. Analogous to many other nuclear receptors, PPARs form heterodimers with the retinoid X receptor and regulate DNA transcription by binding to specific response elements present in target genes.

PPARα (NR1C1) is highly expressed in liver, heart, intestine, skeletal muscle, and various immune cells. Agonists for PPARα include the lipid-lowering fibrate drugs as well as numerous fatty acids and eicosanoids. PPARα is known to play an important role in many different metabolic processes, especially under conditions of fasting, and has proven to be an important regulator of inflammation via inhibition of gene expression.

PPARδ (NR1C2) is ubiquitously expressed but its function has mainly been studied in skin, heart, and skeletal muscle. In the past few years, it has become evident that PPARδ is involved in numerous biological processes including lipid metabolism, wound healing and inflammation.

The most studied PPAR subtype is PPARγ (NR1C3), which is expressed at high levels in adipose tissue, macrophages and vascular cells. PPARγ drives adipocyte differentiation, has important regulatory roles during fat storage and glucose metabolism, and is an important suppressor of inflammation. Importantly, it serves as the molecular target for the thiazolidionedione drugs.

In this chapter we provide an overview of the major functions of the three PPAR subtypes, and focus on their role in metabolic and inflammatory processes.
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