Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 481229
Title Longer Oral Exposure with Modified Sham Feeding Does Not Slow Down Gastric Emptying of Low- and High-Energy-Dense Gastric Loads in Healthy Young Men
Author(s) Wijlens, G.M.; Erkner, A.; Mars, M.; Graaf, C. de
Source The Journal of Nutrition 145 (2015)2. - ISSN 0022-3166 - p. 365 - 371.
DOI https://doi.org/10.3945/jn.114.200584
Department(s) Chair Sensory Science and Eating Behaviour
Chair Nutrition and Health over the Lifecourse
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) food-intake - appetite - stimulation - fat - responses - humans - satiation - ghrelin - liquids - volume
Abstract Background: A long oral exposure to food and a high-energy density of food are shown to increase satiety feelings. The effect of energy density is predominantly caused by an inhibition of gastric emptying. It is hypothesized that prolonging oral exposure may have an additional effect on this inhibition of gastric emptying. However, little human data are available to support this hypothesis. Objective: The objective was to assess the effect of oral exposure duration to food on gastric emptying rate of gastric loads (GLs) low and high in energy density and on satiety feelings. Methods: Twenty-six healthy men (22 ± 3 y, 23 ± 1 kg/m2) participated in a randomized crossover trial with 4 treatments and a control. Treatments consisted of either 1- or 8-min modified sham feeding (MSF) of cake, and a GL of either 100 or 700 kcal infused in the stomach via a nasogastric tube (500 mL, 62.5 mL/min). The control consisted of no MSF and a GL of 500 mL of water. Gastric emptying rate was assessed with a 13C breath test. Breath samples and satiety feelings were collected at fixed time points until 90 min after start of the treatment. Results: Gastric emptying rate and satiety feelings were not affected by duration of MSF (P = 0.27). However, the 700-kcal GL treatments slowed gastric emptying [41% lower area under the curve (AUC)] and increased satiety feelings (22–31% higher AUC) compared with the 100-kcal GL treatments (P <0.001). No interaction between MSF duration and energy density of GL was found (P = 0.44). Conclusions: Higher gastric energy density inhibited gastric emptying and increased satiety feelings in healthy young men. However, prolonging oral exposure to food did not have an additional effect. This study provides more insight in satiety regulation. This trial was registered at trialregister.nl as NTR3601.
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