Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 488855
Title Maturation of the immune response
Author(s) Altena, S.E.C. van; Meijer, B.; Savelkoul, H.F.J.
Source In: Encyclopedia of Immunotoxicology / Vohr, H.W., Springer - ISBN 9783642277863 - p. 1 - 11.
Department(s) Cell Biology and Immunology
Publication type Peer reviewed book chapter
Publication year 2014
Abstract The innate immune system depends on features like extracellular and intracellular pattern recognition receptors (PRR) that recognize general molecular patterns. Different types of PRR have been described, identifying microbe-, pathogen-, and danger-associated molecular patterns (abbreviated as MAMP, PAMP, and DAMP, respectively). PRR enhance ligation and phagocytosis of microbes or have signaling ability allowing activation of the cell. Ligation of extracellular toll-like receptors (TLR) by bacterial ligands like lipopolysaccharide (LPS) (binds to TLR4), peptidoglycan (PGN) (TLR2), and flagellin (TLR5) results in MyD88-dependent production of inflammatory cytokines like interleukin (IL)-1ß, IL-6, IL-8, and partly TNF-a. The expression of TLRs is vast as they are found on the cell membranes of innate immune cells (dendritic cell (DC), macrophages, natural killer cells), cells of the adaptive immunity (T and B lymphocytes), and nonimmune cells (epithelial and en ...
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