Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 490743
Title Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice
Author(s) Hoek-van den Hil, E.F.; Schothorst, E.M. van; Stelt, I. van der; Swarts, J.J.M.; Vliet, M.A. van; Amolo, T.; Vervoort, J.J.M.; Venema, D.P.; Hollman, P.C.H.; Rietjens, I.M.C.M.; Keijer, J.
Source Genes & Nutrition 10 (2015)4. - ISSN 1555-8932 - 13 p.
DOI https://doi.org/10.1007/s12263-015-0469-z
Department(s) VLAG
WIAS
Sub-department of Toxicology
Human and Animal Physiology
Biochemistry
RIKILT - Business unit Contaminants & Toxins
Chair Nutrition and Health over the Lifecourse
RIKILT - BU Toxicology Bioassays & Novel Foods
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) cardiovascular-disease - mediterranean diet - c57bl/6j mice - obese mice - bioavailability - polyphenols - inflammation - metaanalysis - cholesterol - prevention
Abstract Dietary flavonoid intake is associated with reduced risk of cardiovascular diseases, possibly by affecting metabolic health. The relative potency of different flavonoids in causing beneficial effects on energy and lipid metabolism has not been investigated. Effects of quercetin, hesperetin, epicatechin, apigenin and anthocyanins in mice fed a high-fat diet (HF) for 12 weeks were compared, relative to normal-fat diet. HF-induced body weight gain was significantly lowered by all flavonoids (17–29 %), but most by quercetin. Quercetin significantly lowered HF-induced hepatic lipid accumulation (71 %). Mesenteric adipose tissue weight and serum leptin levels were significantly lowered by quercetin, hesperetin and anthocyanins. Adipocyte cell size and adipose tissue inflammation were not affected. The effect on body weight and composition could not be explained by individual significant effects on energy intake, energy expenditure or activity. Lipid metabolism was not changed as measured by indirect calorimetry or expression of known lipid metabolic genes in liver and white adipose tissue. Hepatic expression of Cyp2b9 was strongly downregulated by all flavonoids. In conclusion, all flavonoids lowered parameters of HF-induced adiposity, with quercetin being most effective.
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