Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 494772
Title Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients
Author(s) Orten-Luiten, A.C.B. van; Janse, A.; Dhonukshe-Rutten, R.A.M.; Witkamp, R.F.
Source European Journal of Clinical Pharmacology (2016). - ISSN 0031-6970 - p. 605 - 614.
Department(s) Human Nutrition (HNE)
Chair Nutrition and Health over the Lifecourse
Chair Nutrition and Pharmacology (HNE)
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Adverse drug reaction - Drug-food interaction - Elderly - Polypharmacy - Vitamin D

Purpose: Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevalences of drug use and vitamin D deficiency are estimated. Methods: In a population of 873 community-dwelling Dutch geriatric outpatients, we explored the cross-sectional relationships of polypharmacy (≥5 medications concomitantly used), severe polypharmacy (≥10 medications), and use of twenty-one specific drug groups, with serum 25-hydroxyvitamin D (25(OH)D) by analysis of covariance. Results: Overall prevalence of polypharmacy was 65 %, of severe polypharmacy 22 %. Depending on the cut-off value, prevalence of vitamin D deficiency was 49 % (

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