Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 494834
Title Physiological and transcriptional responses of different industrial microbes at near-zero specific growth rates
Author(s) Ercan, Onur; Bisschops, M.M.M.; Overkamp, Wout; Jørgensen, T.R.; Ram, A.F.; Smid, E.J.; Pronk, J.T.; Kuipers, O.P.; Daran-Lapujade, Pascale; Kleerebezem, Michiel
Source Applied and Environmental Microbiology 81 (2015)17. - ISSN 0099-2240 - p. 5662 - 5670.
DOI http://dx.doi.org/10.1128/AEM.00944-15
Department(s) Food Microbiology Laboratory
VLAG
Host Microbe Interactomics
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract

The current knowledge of the physiology and gene expression of industrially relevant microorganisms is largely based on laboratory studies under conditions of rapid growth and high metabolic activity. However, in natural ecosystems and industrial processes, microbes frequently encounter severe calorie restriction. As a consequence, microbial growth rates in such settings can be extremely slow and even approach zero. Furthermore, uncoupling microbial growth from product formation, while cellular integrity and activity are maintained, offers perspectives that are economically highly interesting. Retentostat cultures have been employed to investigate microbial physiology at (near-)zero growth rates. This minireview compares information from recent physiological and gene expression studies on retentostat cultures of the industrially relevant microorganisms Lactobacillus plantarum, Lactococcus lactis, Bacillus subtilis, Saccharomyces cerevisiae, and Aspergillus niger. Shared responses of these organisms to (near-)zero growth rates include increased stress tolerance and a downregulation of genes involved in protein synthesis. Other adaptations, such as changes in morphology and (secondary) metabolite production, were species specific. This comparison underlines the industrial and scientific significance of further research on microbial (near-)zero growth physiology.

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