Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495129
Title Rates of Lateral Gene Transfer in Prokaryotes : High but Why?
Author(s) Vos, Michiel; Hesselman, M.C.; Beek, T.A. te; Passel, M.W.J. van; Eyre-Walker, Adam
Source Trends in Microbiology 23 (2015)10. - ISSN 0966-842X - p. 598 - 605.
DOI https://doi.org/10.1016/j.tim.2015.07.006
Department(s) Microbiological Laboratory
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Accessory genome - Distribution of fitness effects - Gene content - Gene loss - Lateral gene transfer - Mutation rate
Abstract

Lateral gene transfer is of fundamental importance to the evolution of prokaryote genomes and has important practical consequences, as evidenced by the rapid dissemination of antibiotic resistance and virulence determinants. Relatively little effort has so far been devoted to explicitly quantifying the rate at which accessory genes are taken up and lost, but it is possible that the combined rate of lateral gene transfer and gene loss is higher than that of point mutation. What evolutionary forces underlie the rate of lateral gene transfer are not well understood. We here use theory developed to explain the evolution of mutation rates to address this question and explore its consequences for the study of prokaryote evolution.

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