Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495146
Title Dynamics of adaptation in experimental yeast populations exposed to gradual and abrupt change in heavy metal concentration
Author(s) Gorter, F.A.; Aarts, M.M.G.; Zwaan, B.J.; Visser, Arjan de
Source American Naturalist 187 (2016)1. - ISSN 0003-0147 - p. 110 - 119.
DOI https://doi.org/10.1086/684104
Department(s) Laboratory of Genetics
Groep KoornneefGroep Koornneef
EPS
PE&RC
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Environmental change - Experimental evolution - Genotype-environment interaction - Heavy metals - Pleiotropy - Saccharomyces cerevisiae
Abstract

Directional environmental change is a ubiquitous phe-nomenon that may have profound effects on all living organisms. However, it is unclear how different rates of such change affect the dynamics and outcome of evolution. We studied this question using experimental evolution of heavy metal tolerance in the baker’s yeast Saccharomyces cerevisiae. To this end, we grew replicate lines of yeast for 500 generations in the presence of (1) a constant high concentration of cadmium, nickel, or zinc or (2) a gradually increas-ing concentration of these metals. We found that gradual environ-mental change leads to a delay in fitness increase compared with abrupt change but not necessarily to a different fitness of evolution-ary endpoints. For the nonessential metal cadmium, this delay is due to reduced fitness differences between genotypes at low metal con-centrations, consistent with directional selection to minimize intra-cellular concentrations of this metal. In contrast, for the essential metals nickel and zinc, different genotypes are selected at different concentrations, consistent with stabilizing selection to maintain con-stant intracellular concentrations of these metals. These findings in-dicate diverse fitness consequences of evolved tolerance mechanisms for essential and nonessential metals and imply that the rate of en-vironmental change and the nature of the stressor are crucial deter-minants of evolutionary dynamics.

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