Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495147
Title Protective effects of green tea polyphenols against benzo[a]pyrene-induced reproductive and trans-generational toxic effects in Japanese Medaka (Oryzias latipes)
Author(s) Song, Chuankui; Wang, Yanli; Xiao, Zhengcao; Xiao, Bin
Source Journal of Functional Foods 14 (2015). - ISSN 1756-4646 - p. 354 - 362.
Department(s) Groep KoornneefGroep Koornneef
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Benz[a]pyrene - Deformation - Green tea polyphenols - Japanese Medaka - Reproduction toxicity

In order to investigate the protective effect of green tea polyphenols (GTP) on benzo[a]pyrene (BaP)-induced reproductive and trans-generational toxicity, Japanese Medaka was injected intraperitoneally with BaP alone and co-injected with both BaP and GTP of different concentrations, respectively. Exposure to BaP alone significantly suppressed fecundity, fertilization success, and egg diameter/protein content and markedly induced deformation ratio in F1 generation. However, GTP could help recover reproductive functions, egg quality suppressed by BaP and reduced deformation ratio. VTG-1, a molecular marker of reproductive toxicity, was significantly down-regulated in females exposed to BaP, but a dose-dependent increase was observed in co-exposed groups. Up-regulation of GSH-Px, dose-dependent decrease of CYP1A1, and the GST expression inhibited by BaP was recovered and even markedly up-regulated in the co-exposure groups. These findings show promising protective effects of GTP against BaP-induced reproductive and trans-generational toxicity.

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