Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495474
Title Infectious bronchitis coronavirus inhibits STAT1 signaling and requires accessory proteins for resistance to type I interferon activity
Author(s) Kint, Joeri; Dickhout, Annemiek; Kutter, Jasmin; Maier, H.J.; Britton, Paul; Koumans, Joseph; Pijlman, G.P.; Fros, J.J.; Wiegertjes, G.F.; Forlenza, Maria
Source Journal of Virology 89 (2015)23. - ISSN 0022-538X - p. 12047 - 12057.
DOI http://dx.doi.org/10.1128/JVI.01057-15
Department(s) Cell Biology and Immunology
Laboratory of Virology
PE&RC
WIAS
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract

The innate immune response is the first line of defense against viruses, and type I interferon (IFN) is a critical component of this response. Similar to other viruses, the gammacoronavirus infectious bronchitis virus (IBV) has evolved under evolutionary pressure to evade and counteract the IFN response to enable its survival. Previously, we reported that IBV induces a delayed activation of the IFN response. In the present work, we describe the resistance of IBV to IFN and the potential role of accessory proteins herein. We show that IBV is fairly resistant to the antiviral state induced by IFN and identify that viral accessory protein 3a is involved in resistance to IFN, as its absence renders IBV less resistant to IFN treatment. In addition to this, we found that independently of its accessory proteins, IBV inhibits IFN-mediated phosphorylation and translocation of STAT1. In summary, we show that IBV uses multiple strategies to counteract the IFN response.

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