Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495701
Title Modeling X-linked ancestral origins in multiparental populations
Author(s) Zheng, Chaozhi
Source G3 : Genes Genomes Genetics 5 (2015)5. - ISSN 2160-1836 - p. 777 - 801.
DOI https://doi.org/10.1534/g3.114.016154
Department(s) Biometris (WU MAT)
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Advanced intercross lines (AIL) - Collaborative cross (CC) - Diversity outcross (DO) - Drosophila synthetic population resource (DSPR) - Map expansion - MPP - Multiparent advanced generation inter-cross (MAGIC) - Multiparental populations
Abstract

The models for the mosaic structure of an individual's genome from multiparental populations have been developed primarily for autosomes, whereas X chromosomes receive very little attention. In this paper, we extend our previous approach to model ancestral origin processes along two X chromosomes in a mapping population, which is necessary for developing hidden Markov models in the reconstruction of ancestry blocks for X-linked quantitative trait locus mapping. The model accounts for the joint recombination pattern, the asymmetry between maternally and paternally derived X chromosomes, and the finiteness of population size. The model can be applied to various mapping populations such as the advanced intercross lines (AIL), the Collaborative Cross (CC), the heterogeneous stock (HS), the Diversity Outcross (DO), and the Drosophila synthetic population resource (DSPR). We further derive the map expansion, density (per Morgan) of recom-bination breakpoints, in advanced intercross populations with L inbred founders under the limit of an infinitely large population size. The analytic results show that for X chromosomes the genetic map expands linearly at a rate (per generation) of two-thirds times 1 - 10/(9L) for the AIL, and at a rate of two-thirds times 1 - 1/L for the DO and the HS, whereas for autosomes the map expands at a rate of 1 - 1/L for the AIL, the DO, and the HS.

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