Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Record number 495786
Title Host-pathogen interaction at the intestinal mucosa correlates with zoonotic potential of Streptococcus suis
Author(s) Ferrando, Maria Laura; Greeff, Astrid De; Rooijen, W.J.M. Van; Stockhofe-Zurwieden, Norbert; Nielsen, Jens; Wichgers Schreur, P.J.; Pannekoek, Yvonne; Heuvelink, Annet; Ende, Arie Van Der; Smith, Hilde; Schultsz, Constance
Source The Journal of Infectious Diseases 212 (2015)1. - ISSN 0022-1899 - p. 95 - 105.
Department(s) CVI Infection Biology
CVI Virology
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) clonal complex - intestinal translocation - piglets. - serotype - Streptococcus suis - tight junctions - zoonotic infections

Streptococcus suis has emerged as an important cause of bacterial meningitis in adults. The ingestion of undercooked pork is a risk factor for human S. suis serotype 2 (SS2) infection. Here we provide experimental evidence indicating that the gastrointestinal tract is an entry site of SS2 infection. Methods. We developed a noninvasive in vivo model to study oral SS2 infection in piglets.We compared in vitro interaction of S. suis with human and porcine intestinal epithelial cells (IEC). Results. Two out of 15 piglets showed clinical symptoms compatible with S. suis infection 24-48 hours after ingestion of SS2. SS2 was detected in mesenteric lymph nodes of 40% of challenged piglets. SS2 strains isolated from patients showed significantly higher adhesion to human IEC compared to invasive strains isolated from pigs. In contrast, invasive SS9 strains showed significantly higher adhesion to porcine IEC. Translocation across human IEC, which occurred predominately via a paracellular route, was significantly associated with clonal complex 1, the predominant zoonotic genotype. Adhesion and translocation were dependent on capsular polysaccharide production. Conclusions. SS2 should be considered a food-borne pathogen. S. suis interaction with human and pig IEC correlates with S. suis serotype and genotype, which can explain the zoonotic potential of SS2.

There are no comments yet. You can post the first one!
Post a comment
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.