Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495846
Title Increased prevalence of restless legs syndrome in patients with Crohn’s disease
Author(s) Hoek, Patrick D.; Smits, Marcel G.; Roos, N.M. de; Rijsman, Roselyne M.; Witteman, B.J.M.
Source European Journal of Gastroenterology & Hepatology 27 (2015)8. - ISSN 0954-691X - p. 951 - 955.
DOI http://dx.doi.org/10.1097/MEG.0000000000000386
Department(s) Chair Nutrition and Disease
Human Nutrition (HNE)
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Crohn’s disease - quality of life - restless legs syndrome
Abstract OBJECTIVE:
To determine (a) the incidence of restless legs syndrome (RLS) in patients with Crohn's disease (CD), (b) whether and how the occurrence and severity of RLS is related to severity of CD, and (c) how RLS influences the quality of life of CD patients.
BASIC METHODS:
We carried out a cross-sectional questionnaire study in a random selection of 144 CD patients and 80 controls. Differences were calculated using a χ-test (categorical data), an independent T-test (continuous data, normal distribution), or a Mann-Whitney U-test (continuous data, non-normal distribution). Logistic regression analysis was carried out to establish the relation between CD and RLS after adjusting for risk factors.
MAIN RESULTS:
The prevalence of RLS was 25.7% (37/144) in CD patients compared with 12.5% (10/80) in the control group (P=0.02). CD patients using caffeine and patients with arthralgias had a higher risk for RLS. A higher score on the modified Harvey Bradshaw Index and CD-related surgery were also associated with a higher risk for RLS. CD-related surgery was also associated with a more severe course of RLS. Patients and controls with RLS had a lower score on 'physical functioning', one of the subcategories of the RAND-36 quality-of-life questionnaire.
PRINCIPAL CONCLUSION:
RLS occurs more frequently in patients with CD compared with healthy individuals. A more severe course of CD seems to be associated with a higher risk for RLS. The presence of RLS has a negative influence on quality of life, mainly interfering with physical activities of daily life
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