Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495917
Title Peroxygenase-Catalyzed Oxyfunctionalization Reactions Promoted by the Complete Oxidation of Methanol
Author(s) Ni, Yan; Fernández-Fueyo, Elena; Baraibar, Alvaro Gomez; Ullrich, René; Hofrichter, Martin; Yanase, Hideshi; Alcalde, Miguel; Berkel, W.J.H. van; Hollmann, Frank
Source Angewandte Chemie-International Edition 55 (2016)2. - ISSN 1433-7851 - p. 798 - 801.
DOI https://doi.org/10.1002/anie.201507881
Department(s) Biochemistry
VLAG
Publication type Refereed Article in a scientific journal
Publication year 2016
Keyword(s) Heme proteins - Hydrogen peroxide - Hydroxylation - Oxidation - Peroxygenases
Abstract

Peroxygenases catalyze a broad range of (stereo)selective oxyfunctionalization reactions. However, to access their full catalytic potential, peroxygenases need a balanced provision of hydrogen peroxide to achieve high catalytic activity while minimizing oxidative inactivation. Herein, we report an enzymatic cascade process that employs methanol as a sacrificial electron donor for the reductive activation of molecular oxygen. Full oxidation of methanol is achieved, generating three equivalents of hydrogen peroxide that can be used completely for the stereoselective hydroxylation of ethylbenzene as a model reaction. Overall we propose and demonstrate an atom-efficient and easily applicable alternative to established hydrogen peroxide generation methods, which enables the efficient use of peroxygenases for oxyfunctionalization reactions.

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