Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495923
Title Toward a new european threshold to discriminate illegally administered from naturally occurring thiouracil in livestock
Author(s) Wauters, Jella; Vanden Bussche, Julie; Bizec, Bruno Le; Kiebooms, J.A.L.; Dervilly-Pinel, Gaud; Prevost, Stéphanie; Wozniak, Barbara; Sterk, S.S.; Grønningen, Dag; Kennedy, D.G.; Russell, Sandra; Delahaut, Philippe; Vanhaecke, Lynn
Source Journal of Agricultural and Food Chemistry 63 (2015)5. - ISSN 0021-8561 - p. 1339 - 1346.
DOI http://dx.doi.org/10.1021/jf504475f
Department(s) RIKILT - Business unit Dierbehandelingsmiddelen
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) endogenous - European - LC-MS/MS - thiouracil - threshold - urine
Abstract

Thiouracil is a thyrostat inhibiting the thyroid function, resulting in fraudulent weight gain if applied in the fattening of livestock. The latter abuse is strictly forbidden and monitored in the European Union. Recently, endogenous sources of thiouracil were identified after frequently monitoring low-level thiouracil positive urine samples and a "recommend concentration" (RC) of 10 ∼g/L was suggested by the EURL to facilitate decision-making. However, the systematic occurrence of urine samples exceeding the RC led to demands for international surveys defining an epidemiologic threshold. Therefore, six European member states (France, Poland, The Netherlands, United Kingdom, Norway, and Belgium) have shared their official thiouracil data (2010-2012) collected from bovines, porcines, and small livestock with 95 and 99% percentiles of 8.1 and 18.2 ∼g/L for bovines (n = 3894); 7.4 and 13.5 ∼g/L for porcines (n = 654); and 7.4 ∼g/L (95% only) for small livestock (n = 85), respectively. Bovine percentiles decreased with the animal age (nonadults had significantly higher levels for bovines), and higher levels were observed in male bovines compared to female bovines.

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