Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 495992
Title Metabolic Engineering of TCA Cycle for Production of Chemicals
Author(s) Vuoristo, K.S.; Mars, A.E.; Sanders, J.P.M.; Eggink, G.; Weusthuis, R.A.
Source Trends in Biotechnology 34 (2016)3. - ISSN 0167-7799 - p. 191 - 197.
Department(s) Bioprocess Engineering
FBR Bioconversion
Biobased Products
Publication type Refereed Article in a scientific journal
Publication year 2016
Abstract The tricarboxylic acid (TCA) cycle has been used for decades in the microbial production of chemicals such as citrate, L-glutamate, and succinate. Maximizing yield is key for cost-competitive production. However, for most TCA cycle products, the maximum pathway yield is lower than the theoretical maximum yield (YE). For succinate, this was solved by creating two pathways to the product, using both branches of the TCA cycle, connected by the glyoxylate shunt (GS). A similar solution cannot be applied directly for production of compounds from the oxidative branch of the TCA cycle because irreversible reactions are involved. Here, we describe how this can be overcome and what the impact is on the yield.

Metabolic Engineering of TCA Cycle for Production of Chemicals (PDF Download Available). Available from: [accessed Feb 5, 2016].
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