Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 496038
Title Gnotobiology and the Study of Complex Interactions between the Intestinal Microbiota, Probiotics, and the Host
Author(s) Tlaskalova-Hogenova, Helena; Kverka, Miloslav; Verdu, E.F.; Wells, J.M.
Source In: Mucosal Immunology: Fourth Edition Elsevier - ISBN 9780124159754 - p. 109 - 133.
Department(s) Host Microbe Interactomics
Publication type Peer reviewed book chapter
Publication year 2015
Keyword(s) Animal models - Dysbiosis - Germ-free - Gnotobiology - Gut - Immunomodulation - Inflammatory diseases - Microbiome

Gnotobiology technology for the breeding of experimental mice originated in the first half of the twentieth century. Earlier studies conducted in germ-free animals revealed the importance of the microbiota in the development of the immune system, gut morphology, and metabolism. These seminal studies have been confirmed and complemented by recent work that exploits the use of modern gnotobiotic technology as well as the combination of high-throughput molecular techniques to study the composition and metabolic capacity of the intestinal microbiota. From a historical perspective, this chapter discusses the evolution of theory concerning complex host-microbiota interactions and probiotics species. It also reviews the current evidence for a role of maladaptive interactions in the development of disease within and beyond the gastrointestinal tract.

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