Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 496072
Title Q fever (Coxiella burnetii): A bleuprint for outbreak
Author(s) Roest, H.I.J.; Frangoulidis, D.
Source In: Zoonoses-Infections Affecting Humans and Animals / Sing, Andreas, Dordrecht : Springer Science + Business Media - ISBN 9789401794572 - p. 317 - 334.
DOI https://doi.org/10.1007/978-94-017-9457-2_12
Department(s) CVI Bacteriology and Epidemiology
Publication type Peer reviewed book chapter
Publication year 2015
Abstract About 80 years ago, Q fever research began due to human outbreaks
of unknown origin, associated with domestic animals. Since then, some but not
all characteristics of this “query” disease, caused by the intracellular bacterium
Coxiella burnetii were revealed. In this chapter the bacteriology of the bacterium,
clinical presentation, epidemiology and transmission of the disease in humans and
animals are presented. Domestic small ruminants are the main source of human
Q fever. Although Q fever is considered to be an occupational disease, outbreaks
have a major public health impact and attract most attention. The Dutch Q fever
outbreak, involving 4000 human cases over the years 2007–2010, is an example
of how Q fever can re-emerge from an endemic state into an outbreak of unforeseen dimension. In this outbreak the epidemiological link between dairy goats and human cases was confirmed by genotyping for the first time. This was possible due to the previous development of genotyping assays that are applicable on clinical material. Although Q fever seems to be a blue print for outbreaks it is not known yet what factors are essential to cause outbreaks and how they interact. To prevent outbreaks, a better understanding of these factors and their interaction is necessary and research should therefore focus on this.
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