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Record number 496074
Title Preliminary Evaluation of a Bunyavirus Vector for Cancer Immunotherapy
Author(s) Oreshkova, N.D.; Spel, L.; Vloet, R.P.M.; Wichgers Schreur, P.J.; Moormann, R.J.M.; Boes, M.; Kortekaas, J.A.
Source Journal of Virology 89 (2015)17. - ISSN 0022-538X - p. 9124 - 9127.
DOI http://dx.doi.org/10.1128/JVI.01105-15
Department(s) CVI Virology
Publication type Refereed Article in a scientific journal
Publication year 2015
Abstract Replicon particles of Rift Valley fever virus, referred to as nonspreading Rift Valley fever virus (NSR), are intrinsically safe and highly immunogenic. Here, we demonstrate that NSR-infected human dendritic cells can activate CD8+ T cells in vitro and that prophylactic and therapeutic vaccinations of mice with NSR encoding a tumor-associated CD8 peptide can control the outgrowth of lymphoma cells in vivo. These results suggest that the NSR system holds promise for cancer immunotherapy.
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