Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Record number 496336
Title Diagnosis of Fusarium Infections : Approaches to Identification by the Clinical Mycology Laboratory
Author(s) Diepeningen, A.D. van; Brankovics, Balázs; Iltes, Jearidienne; Lee, T.A.J. van der; Waalwijk, Cees
Source Current Fungal Infection Reports 9 (2015)3. - ISSN 1936-3761 - p. 135 - 143.
DOI https://doi.org/10.1007/s12281-015-0225-2
Department(s) PRI Bioint Diagnostics, Food Safety & Phytosanitary
Publication type Refereed Article in a scientific journal
Publication year 2015
Keyword(s) Antifungal susceptibility - Clinical observations - DNA-based diagnostic tools - Fusarium - Multi-locus sequence typing - Peptide-based diagnostic tools
Abstract

Infections caused by the genus Fusarium have emerged over the past decades and range from onychomycosis and keratitis in healthy individuals to deep and disseminated infections with high mortality rates in immune-compromised patients. As antifungal susceptibility can differ between the different Fusarium species, identification at species level is recommended. Several clinical observations as hyaline hyphae in tissue, necrotic lesions in the skin and positive blood tests with fungal growth or presence of fungal cell wall components may be the first hints for fusariosis. Many laboratories rely on morphological identification, but especially multi-locus sequencing proves better to discriminate among members of the species complexes involved in human infection. DNA-based diagnostic tools have best discriminatory power when based on translation elongation factor 1-α or the RNA polymerase II second largest subunit. However, assays based on the detection of other fusarial cell compounds such as peptides and cell wall components may also be used for identification. The purpose of this review is to provide an overview and a comparison of the different tools currently available for the diagnosis of fusariosis.

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